Effect of intragastric pH on mucosal protective action of sucralfate.
نویسندگان
چکیده
منابع مشابه
Effect of intragastric pH on mucosal protective action of sucralfate.
Acid intragastric pH is believed to be mandatory for mucosal protective action of sucralfate, but evidence for its efficacy at neutral pH is lacking. The effect of sucralfate on gastric mucosal erosions induced by oral administration of aspirin and bile acids at acidic pH of 1.5 and 3.9, and near neutral pH of 6.5 was investigated in 320 rats. The effect of sucralfate on the intragastric pH fou...
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15 صفحه اولEffect of sucralfate on gastric mucosal blood flow in rats.
Sucralfate possesses site protective and cytoprotective actions and heals ulcers effectively, but its effect on gastric mucosal blood flow is unknown. Using an ex vivo gastric chamber preparation, we studied the effect of sucralfate on gastric mucosal blood flow in rats by laser doppler flowmetry. Under both fasting and fed states, measurements of gastric mucosal blood flow and damage were made...
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ژورنال
عنوان ژورنال: Gut
سال: 1988
ISSN: 0017-5749
DOI: 10.1136/gut.29.10.1379